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All medicines can have side effectsSometimes they are seriousbut most of the time they are notYou may need medical treatment if you get some of the side effects.

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A study in six healthy volunteers has shown a significant increase in peak diltiazem plasma levels58and area-under-the-curve53after a 1-week course of cimetidine at 1200 mg per day and a single dose of diltiazem 60 mgRanitidine produced smallernonsignificant increasesThe effect may be mediated by cimetidine's known inhibition of hepatic cytochrome P-450the enzyme system responsible for the first-pass metabolism of diltiazemPatients currently receiving diltiazem therapy should be carefully monitored for a change in pharmacological effect when initiating and discontinuing therapy with cimetidineAn adjustment in the diltiazem dose may be warranted.

CARDIZEM 30-mg tablets are supplied in bottles of 100NDC 0187-0771-47and 500NDC 0187-0771-55Each light greenround tablet is engraved with MARION on one side and 1771 on the other.

Diltiazem is excreted in human milkOne report suggests that concentrations in breast milk may approximate serum levelsIf use of CARDIZEM medications without perscriptions….. is deemed essentialan alternative method of infant feeding should be instituted.

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cardizem is contraindicated in 1 patients with sick sinus syndrome except in the presence of a functioning ventricular pacemaker, 2 patients with second-or third-degree av block except in the presence of a functioning ventricular pacemaker, 3 patients with hypotension less than 90 mm hg systolic , 4 patients who have demonstrated hypersensitivity to the drug, and 5 patients with acute myocardial infarction and pulmonary congestion documented by x-ray on admission.

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